Prostaglandin F synthase (PGFS)

1. Prostaglandin F synthase (PGFS) has dual catalytic activities (PGD₂ → 9α,11β-PGF₂ and

PGH₂ → PGF_2α)

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2. Crystal structures of prostaglandin F synthase (PGFS) complexed with NADP⁺ and PGD₂ and rutin were determined.

Structure of PGFS with NADP⁺ and PGD₂

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3. Catalytic mechanism of PGD₂ → 9α,11β-PGF₂ reaction

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Publications:

● Komoto, J., Yamada, T., Watanabe, K., & Takusagawa, F. (2004). Crystal structure of Human prostaglandin F synthase (AKR1C3). Biochemistry 43, 2188-2198.